A rare inflammatory connective tissue illness called scleroderma causes abnormal skin thickening. Collagen makes up connective tissue, which holds other body tissues together and provides support. Scleroderma comes in various forms. Different varieties can affect the entire body and internal organs (systemic), while others just affect certain, localized areas of the body. Systemic progressive sclerosis is another name for scleroderma. Scleroderma's precise origin is not known. Systemic sclerosis, usually referred to as scleroderma, is a collection of uncommon disorders that cause the skin to tighten and stiffen. Additionally, it could affect the digestive system, internal organs, and blood vessels. Scleroderma is frequently labelled as "limited" or "diffuse," which merely describes how much skin is affected. Both forms may involve any other organ or vascular issues. Skin alone is impacted by localized scleroderma, commonly known as morphea. Scleroderma has no known cure, although therapies can reduce symptoms, halt progression, and enhance quality of life.
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